Caribbean, Anguilla. Anguilla was first settled by Amerindian tribes who migrated from South America. Anguilla is a flat, low-lying island of coral and limestone in the Caribbean Sea, east of Puerto Rico. The soil is generally thin and poor, supporting only scrub vegetation. Its main industries are tourism, offshore incorporation and management, offshore banking, and fishing. Many insurance and financial business are headquartered in Anguilla.