Facsimilie page of a notebook of Charles Darwin of 1837. Charles Darwin,1809 -1882. British Naturalist. From the book "The Life and Letters of Charles Darwin", Volume 2. Published London 1887. FROM A DARWIN NOTE-BOOK OF 1837. Wherein he formulates the concept of the Origen of Species. led to comprehend true affinities. My theory would give zest to recent and Fossil Comparative Anatomy: it would lead to study of instincts, heredity, and mind heredity, whole metaphysics, it would lead to closest examination of hybridity and generation, causes of change in order to know what we have come from and to what we tend, to what circumstances favour crossing and what prevents it, this and direct examination of direct passages of structure in species, might lead to laws of change, which would then be main object of study, to guide our speculations.