Beta secretase enzyme. Molecular model of the enzyme beta secretase bound to an inhibitor molecule. Beta secretase is a membrane-associated aspartic protease, and is also known as beta-site amyloid precursor protein cleaving enzyme 1 (BACE-1). It is a transmembrane protein that is thought to play a role in Alzheimer's disease through the build up of amyloid plaques in the brain. Drugs that inhibit this enzyme may help slow the progress of the disease.
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Creative#:
TOP10705013
Source:
達志影像
Authorization Type:
RM
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須由TPG 完整授權
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No
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BETASECRETASEBACE1DRUGMOLECULEPROTEINBIOMOLECULEMACROMOLECULEENZYMEINHIBITORCOMPLEXINHIBITINGBINDINGINTERACTINGBIOCHEMISTRYBIOLOGYPROTEOMICSNEUROLOGYARTWORKILLUSTRATIONMOLECULARMODELALZHEIMER'SDISEASEAMYLOIDAMYLOIDPLAQUESAMYLOIDPRECURSORPROTEINCLEAVINGENZYMEASP2ASPARTYLPROTEASE2BACEBETA-SECRETASEBETA-SITEBETA-SITEAMYLOIDPRECURSORPROTEINCLEAVINGENZYME1BETA-SITEAPPCLEAVINGENZYME1CUTOUTCUTOUTSCUT-OUTCUT-OUTSCUTOUTCUTOUTSMEMAPSIN-2MEMBRANE-ASSOCIATEDASPARTICPROTEASENEUROLOGICALSTRUCTURETRANSMEMBRANEPROTEINWHITEBACKGROUNDBIOCHEMICALBIOLOGICAL
112ALZHEIMER'SAMYLOIDAMYLOIDAMYLOIDAMYLOIDAPPARTWORKASP2ASPARTICASPARTYLBACEBACE1BACKGROUNDBETABETA-SECRETASEBETA-SITEBETA-SITEBETA-SITEBINDINGBIOCHEMICALBIOCHEMISTRYBIOLOGICALBIOLOGYBIOMOLECULECLEAVINGCLEAVINGCLEAVINGCOMPLEXCUTCUTCUT-OUTCUT-OUTSCUTOUTCUTOUTSDISEASEDRUGENZYMEENZYMEENZYMEENZYMEILLUSTRATIONINHIBITINGINHIBITORINTERACTINGMACROMOLECULEMEMAPSIN-2MEMBRANE-ASSOCIATEDMODELMOLECULARMOLECULENEUROLOGICALNEUROLOGYOUTOUTSPLAQUESPRECURSORPRECURSORPROTEASEPROTEASEPROTEINPROTEINPROTEINPROTEINPROTEOMICSSECRETASESTRUCTURETRANSMEMBRANEWHITE