IMAGINE is a state-of-the art neutron image-plate single crystal diffractometer at ORNL's High Flux Isotope Reactor. The image shows a protein crystal sample on a goniometer head. Understanding essential biochemical processes at the atomic level is the key to discoveries in the bioenergy, biomedical, and pharmaceutical sciences. IMAGINE's high resolution allows researchers to study proteins and macromolecules, including those involved in processes such as biofuels production, the development of disease, and drug design. The IMAGINE diffractometer provides atomic resolution information on inorganic, organic, metallo-organic, and macromolecular single crystals that enables their chemical, physical, and biological structure and function to be understood. IMAGINE benefits communities with interest in pharmaceuticals, minerals and materials, small molecules, molecular organo-metallic complexes and metal-organic frameworks and enables the neutron crystal structure of oligo-nucleotides and proteins to be determined at or near atomic resolutions. The High Flux Isotope Reactor (or HFIR) is a nuclear research reactor located at Oak Ridge National Laboratory (ORNL).