Epilepsy and treatment of excitatory glutamatergic synapses and GABAergic, inhibitory. At the top, an excitable synapse. The vesicles of the presynaptic terminal release glutamate (yellow) which, in contact with the ionotropic AMPA and KAR receptors (pink) of the postsynaptic neuron, triggers the release of Ca2 +, Na + and K +. Calcium, potassium and sodium channels are located on the presynaptic termination. Below, an inhibitory synapse. The presynaptic termination releases GABA (pink) which, in contact with the GABA A receptors (green) of the postsynaptic neuron, allows the passage of Cl-. A GAT channel is located on the left edge of the presynaptic terminus that recovers GABA that is converted to metabolites prior to their recombination into GABA in the vesicles.