The Great Fire of Rome was an urban fire started between 18-19 July, 64 CE, during the reign of Emperor Nero. It caused widespread destruction throughout the city, burning for over six days. Many accounts claim that Nero was responsible for initiating the fire, to create space to build his new palatial complex, the Domus Aurea.

In response to the accusations, Nero blamed the fire on Rome's Christian community, resulting in the first organised persecution against Christianity in the empire.