Pedrini was born in Fermo, Italy. He was the founder of the Xizhimen Church in Beijing. He was teacher of music of some Emperor Kangxi??? sons and co-author of the first treaty about Western Music theory ever written in Chinese. He left Europe for China in 1703, eventually arriving in Beijing in 1711. He died in Beijing in 1746 and is interred there. His funeral expenses were paid by the Qianlong Emperor.